Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.40 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.40 |
| ▸ | BMPR2 | Q13873 | 2/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1601096 | 0.90 | MAPT (0.43) | MAPK10TGFBR1ACVR1KDRPRKAB1 | |
| SCHEMBL1601146 | 0.82 | CNR2 (0.43) | KDM4EMAPT | |
| SCHEMBL1602303 | 0.68 | ABL1 (0.47) | TGFBR1ACVR1BMPR1BBMPR1AACVRL1 | |
| SCHEMBL5133066 | 0.65 | LMNA (0.72) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL1602499 | 0.62 | SLC6A4 (0.40) | — | |
| SCHEMBL3065789 | 0.62 | JAK2 (0.48) | MAPK10TGFBR1ACVR1KDRPRKAB1 | |
| SCHEMBL22070450 | 0.61 | IL2 (0.49) | MAPK10TGFBR1ACVR1KDRPRKAB1 | |
| SCHEMBL18318310 | 0.61 | CNR2 (0.49) | SYKKCNH2 | |
| SCHEMBL30440657 | 0.61 | LTA4H (0.66) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL17754956 | 0.60 | MAPK10 (0.52) | MAPK10TGFBR1ACVR1KDRPRKAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |