Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17934412 | 0.82 | CYP2D6 (0.46) | TDP1TP53ALDH1A1PRSS1PRSS2 | |
| SCHEMBL6547363 | 0.81 | TDP1 (0.48) | TDP1TP53NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL29883022 | 0.81 | TDP1 (0.48) | TDP1TP53NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL10873220 | 0.80 | ALDH1A1 (0.50) | TDP1TP53ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL11300977 | 0.79 | TDP1 (0.46) | TDP1TP53NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL674175 | 0.79 | TDP1 (0.46) | TDP1TP53NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL29444190 | 0.79 | TDP1 (0.46) | TDP1TP53NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL23978126 | 0.77 | TDP1 (0.44) | TDP1TP53NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL2107802 | 0.77 | PRSS1 (0.48) | TDP1TP53NFE2L2ALDH1A1PRSS1 | |
| SCHEMBL11601038 | 0.77 | TDP1 (0.44) | TDP1TP53NFE2L2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4306529-A2 | FGFR INHIBITORS AND METHODS OF USE THEREOF | Relay Therapeutics, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| WO-2020102100-A9 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2022-01-06 | — | — | WO | disclosed |
| EP-2598946-B1 | POLYMERIZABLE COMPOSITION | FUJIFILM CORP (JP) | 2019-04-03 | — | — | EP | disclosed |
| EP-3287441-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2018-02-28 | — | — | EP | disclosed |