Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19909349 | 0.85 | CCNB2 (0.55) | IKBKBCHUKCCNB2CDK1CCNB1 | |
| SCHEMBL4925656 | 0.76 | KIT (0.56) | KITBRAF | |
| SCHEMBL3319702 | 0.76 | PDGFRB (0.45) | MEN1MAPTKMT2AKITALDH1A1 | |
| SCHEMBL2978828 | 0.75 | KIT (0.50) | MAPTKITKDM4EALDH1A1LMNA | |
| SCHEMBL2982155 | 0.74 | CHEK1 (0.43) | KITCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL5609143 | 0.73 | APP (0.55) | MEN1MAPTKMT2AKDM4EDHFR | |
| SCHEMBL3322959 | 0.73 | ABL1 (0.56) | MAPTKITKDM4EALDH1A1LMNA | |
| SCHEMBL4475824 | 0.73 | MAPT (0.52) | MEN1MAPTKMT2AKITKDM4E | |
| SCHEMBL2980544 | 0.73 | KIT (0.49) | KIT | |
| SCHEMBL4476999 | 0.73 | KIT (0.49) | MEN1MAPTKMT2AKITKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935248-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2018-02-28 | — | — | EP | disclosed |