Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 2/20 | 0.55 |
| ▸ | CDK1 | P06493 | 2/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.55 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.55 |
| ▸ | GSK3A | P49840 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | CHUK | O15111 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19909246 | 0.85 | MEN1 (0.42) | CCNB2CDK1CCNB1CCNB3GSK3A | |
| SCHEMBL28043442 | 0.79 | RIPK1 (0.74) | CCNB2CDK1CCNB1CCNB3GSK3A | |
| SCHEMBL18949203 | 0.77 | KIT (0.43) | CCNB2CDK1CCNB1CCNB3GSK3A | |
| SCHEMBL15824092 | 0.76 | KIT (0.55) | — | |
| SCHEMBL1779950 | 0.75 | KDM4E (0.57) | CCNB2CDK1CCNB1CCNB3GSK3A | |
| SCHEMBL4476999 | 0.74 | KIT (0.49) | CDK1GSK3AGSK3BCDK5DYRK1A | |
| SCHEMBL4475824 | 0.74 | MAPT (0.52) | CDK1GSK3AGSK3BCDK5CSF1R | |
| SCHEMBL19909553 | 0.74 | KIT (0.54) | — | |
| SCHEMBL4925656 | 0.73 | KIT (0.56) | — | |
| SCHEMBL3319702 | 0.72 | PDGFRB (0.45) | CSF1RCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935248-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2018-02-28 | — | — | EP | disclosed |