Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 5/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 7/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 3/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | ULK1 | O75385 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23912153 | 0.78 | BRD4 (0.57) | BRD4PIK3CGKITCCNB2CDK1 | |
| SCHEMBL19909156 | 0.78 | BRD4 (0.51) | BRD4PIK3CGKITRIPK1CCNB2 | |
| SCHEMBL18944010 | 0.78 | BRD4 (0.51) | BRD4PIK3CGKITRIPK1CCNB2 | |
| SCHEMBL18918667 | 0.75 | ULK1 (0.59) | BRD4PIK3CGKITULK1 | |
| SCHEMBL23912160 | 0.75 | BRD4 (0.48) | BRD4PIK3CGKITRIPK1CCNB2 | |
| SCHEMBL30236422 | 0.73 | KIT (0.68) | KIT | |
| SCHEMBL15824723 | 0.73 | KIT (0.68) | KIT | |
| SCHEMBL1778505 | 0.73 | RIPK1 (0.74) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL15020472 | 0.72 | CYP19A1 (0.54) | BRD4PIK3CGKITRIPK1CCNB2 | |
| SCHEMBL1772615 | 0.72 | RIPK1 (0.54) | BRD4PIK3CGKITRIPK1CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935248-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2018-02-28 | — | — | EP | disclosed |