Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | HTT | P42858 | 4/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | BTK | Q06187 | 12/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19909686 | 0.99 | ALDH1A1 (0.63) | ALDH1A1HTTNPSR1BTKSMN1; SMN2 | |
| SCHEMBL19909657 | 0.89 | BTK (0.66) | ALDH1A1HTTNPSR1BTKSMN1; SMN2 | |
| SCHEMBL16075347 | 0.89 | BTK (0.56) | ALDH1A1HTTNPSR1BTKSMN1; SMN2 | |
| SCHEMBL16075279 | 0.85 | BTK (0.66) | BTK | |
| SCHEMBL19909753 | 0.84 | ALDH1A1 (0.62) | ALDH1A1HTTNPSR1SMN1; SMN2TDP1 | |
| SCHEMBL16075270 | 0.83 | BTK (0.66) | BTK | |
| SCHEMBL16075328 | 0.83 | BTK (0.50) | ALDH1A1HTTNPSR1BTK | |
| SCHEMBL19909740 | 0.83 | BTK (0.50) | ALDH1A1HTTNPSR1BTKSMN1; SMN2 | |
| SCHEMBL27047633 | 0.82 | KMT2A (0.56) | ALDH1A1HTTNPSR1BTKSMN1; SMN2 | |
| SCHEMBL16075346 | 0.82 | BTK (0.53) | ALDH1A1HTTNPSR1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970163-B1 | 5-THIAZOLECARBOXAMIDE DERVATIVES AND THEIR USE AS BTK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2018-02-28 | — | — | EP | disclosed |