Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.72 |
| ▸ | AKT1 | P31749 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1991069 | 1.00 | ROCK2 (0.72) | ROCK2AKT1CYP1A2CYP2C9HPGD | |
| SCHEMBL1989842 | 0.88 | ROCK2 (0.72) | ROCK2AKT1CYP1A2CYP2C9HPGD | |
| SCHEMBL1989840 | 0.88 | ROCK2 (0.72) | ROCK2AKT1CYP1A2CYP2C9HPGD | |
| SCHEMBL1988857 | 0.85 | ROCK2 (0.72) | ROCK2AKT1CYP1A2CYP2C9HPGD | |
| SCHEMBL1988854 | 0.85 | ROCK2 (0.72) | ROCK2AKT1CYP1A2CYP2C9HPGD | |
| SCHEMBL1986233 | 0.84 | ROCK2 (1.00) | ROCK2AKT1CYP1A2CYP2C9HPGD | |
| SCHEMBL1988406 | 0.84 | ROCK2 (1.00) | ROCK2AKT1CYP1A2CYP2C9HPGD | |
| SCHEMBL1986348 | 0.79 | ROCK2 (0.62) | ROCK2AKT1CYP1A2CYP2C9HPGD | |
| SCHEMBL1992425 | 0.79 | ROCK2 (0.76) | ROCK2AKT1CYP1A2CYP2C9HPGD | |
| SCHEMBL1989017 | 0.78 | ROCK2 (0.65) | ROCK2AKT1CYP1A2CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | ROCK1, RHOA, RHOT2 | ROCK2 4/4885AKT1 31/4885CYP1A2 1288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.