SCHEMBL1991273

SCHEMBL1991273

CC(C)(C)OC(=O)NC1CCN(c2ccc([N+](=O)[O-])nc2)C1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.49
CHRNB4 P30926 2/20 0.49
CHRNA3 P32297 2/20 0.49
CHRNA4 P43681 2/20 0.49
MAPT P10636 5/20 0.49
RAB9A P51151 1/20 0.48
CKS1B P61024 1/20 0.48
SKP1 P63208 1/20 0.48
SKP2 Q13309 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.46
MET P08581 1/20 0.46
MAP4K4 O95819 2/20 0.46
PIM1 P11309 1/20 0.46
PIM3 Q86V86 1/20 0.46
PIM2 Q9P1W9 1/20 0.46
POLB P06746 1/20 0.46
PDE10A Q9Y233 1/20 0.45
JAK3 P52333 1/20 0.44
BTK Q06187 1/20 0.44
SUV39H2 Q9H5I1 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30542791 1.00 CHRNB2 (0.49) CHRNB2CHRNB4CHRNA3CHRNA4MAPT
SCHEMBL30542725 1.00 CHRNB2 (0.49) CHRNB2CHRNB4CHRNA3CHRNA4MAPT
SCHEMBL15252451 0.95 MAPT (0.51) CHRNB2CHRNB4CHRNA3CHRNA4MAPT
SCHEMBL17054767 0.94 MAP4K4 (0.53) CHRNB2CHRNB4CHRNA3CHRNA4MAPT
SCHEMBL17055303 0.94 MAP4K4 (0.53) CHRNB2CHRNB4CHRNA3CHRNA4MAPT
SCHEMBL25374207 0.94 MAP4K4 (0.53) CHRNB2CHRNB4CHRNA3CHRNA4MAPT
SCHEMBL29744447 0.94 MAP4K4 (0.53) CHRNB2CHRNB4CHRNA3CHRNA4MAPT
SCHEMBL31256861 0.94 MAP4K4 (0.53) CHRNB2CHRNB4CHRNA3CHRNA4MAPT
SCHEMBL3702193 0.85 MAPT (0.56) MAPTCKS1BSKP1SKP2PIM1
SCHEMBL13418950 0.84 CHRNB2 (0.48) CHRNB2CHRNB4CHRNA3CHRNA4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260146042-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2026-05-28 US disclosed
EP-4482839-A2 STIMULATOR OF INTERFERON GENES (STING) MODULATORS, AND COMPOSITIONS AND METHODS THEREOF Geode Therapeutics Inc. (US) 2025-01-01 EP disclosed
US-20240043428-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES ASTEX THERAPEUTICS LTD. (GB) 2024-02-08 US disclosed
WO-2023158862-A2 STIMULATOR OF INTERFERON GENES (STING) MODULATORS, AND COMPOSITIONS AND METHODS THEREOF GEODE THERAPEUTICS INC. (US) 2023-08-24 WO disclosed
US-20210253578-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES ASTEX THERAPEUTICS LTD. (GB) 2021-08-19 US disclosed
US-20180155351-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2018-06-07 US disclosed
US-20170183352-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2017-06-29 US disclosed
US-20170183352-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2017-06-29 US disclosed
US-9670202-B2 Substituted triazolopyridines BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-06-06 US disclosed
EP-3004092-B1 SUBSTITUTED TRIAZOLOPYRIDINES Bayer Pharma AG (DE) 2017-03-22 EP disclosed
US-8415355-B2 Pyrrolopyrimidine compounds and their uses NOVARTIS AG (CH) 2013-04-09 US disclosed
US-8415355-B2 Pyrrolopyrimidine compounds and their uses NOVARTIS AG (CH) 2013-04-09 US disclosed
US-8415355-B2 Pyrrolopyrimidine compounds and their uses NOVARTIS AG (CH) 2013-04-09 US disclosed
US-20110152244-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2011-06-23 US disclosed
US-20110152244-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2011-06-23 US disclosed
EP-2331547-A1 PYRROLOPYRIMIDINE COMPOUNDS AS CDK INHIBITORS Novartis AG (CH) 2011-06-15 EP disclosed
US-20100105653-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES NOVARTIS AG 2010-04-29 US disclosed
US-20100105653-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES NOVARTIS AG 2010-04-29 US disclosed
WO-2010020675-A1 PYRROLOPYRIMIDINE COMPOUNDS AS CDK INHIBITORS NOVARTIS AG (CH) 2010-02-25 WO disclosed
WO-2010020675-A1 PYRROLOPYRIMIDINE COMPOUNDS AS CDK INHIBITORS NOVARTIS AG (CH) 2010-02-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260146042-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES CDK9, CDK6, CDK7 CHRNB2 4855/4885CHRNB4 4865/4885CHRNA3 4793/4885
US-20110152244-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES CDK6, CDK8, CDK7 CHRNB2 4852/4885CHRNB4 4799/4885CHRNA3 4806/4885
US-20170183352-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES CDK6, CDK8, CDK7 CHRNB2 4852/4885CHRNB4 4799/4885CHRNA3 4806/4885
US-20240043428-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES CDK6, CDK8, CDK7 CHRNB2 4852/4885CHRNB4 4799/4885CHRNA3 4806/4885
US-20180155351-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES CDK6, CDK8, CDK7 CHRNB2 4852/4885CHRNB4 4799/4885CHRNA3 4806/4885
US-20210253578-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES CDK6, CDK8, CDK7 CHRNB2 4852/4885CHRNB4 4799/4885CHRNA3 4806/4885
US-20100105653-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES CDK6, CDK8, CDK7 CHRNB2 4852/4885CHRNB4 4799/4885CHRNA3 4806/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.