SCHEMBL19913192

SCHEMBL19913192

Cc1cc(C)cc(-c2ccc3c(c2)c2cc(-c4cc(C)cc(C(F)(F)F)c4)ccc2n3-c2cc(-c3ccncc3)cc(-n3c4ccc(-c5cc(C)cc(C(F)(F)F)c5)cc4c4cc(-c5cc(C(F)(F)F)cc(C(F)(F)F)c5)ccc43)c2C#N)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 3/20 0.35
EPHX2 P34913 1/20 0.32
DHODH Q02127 1/20 0.32
S1PR1 P21453 1/20 0.32
S1PR3 Q99500 1/20 0.32
PSEN1 P49768 2/20 0.32
PSEN2 P49810 2/20 0.32
APH1B Q8WW43 2/20 0.32
NCSTN Q92542 2/20 0.32
APH1A Q96BI3 2/20 0.32
PSENEN Q9NZ42 2/20 0.32
RXRA P19793 2/20 0.32
RXRG P48443 1/20 0.32
AR P10275 1/20 0.32
ICMT O60725 2/20 0.31
CYP11B2 P19099 2/20 0.31
CYP11B1 P15538 1/20 0.31
RXRB P28702 1/20 0.31
AAK1 Q2M2I8 1/20 0.31
NAAA Q02083 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19912405 0.93 MAPK14 (0.34) KIF11PSEN1PSEN2APH1BNCSTN
SCHEMBL19913191 0.93 MAPK14 (0.34) KIF11PSEN1PSEN2APH1BNCSTN
SCHEMBL19912559 0.93 RXRA (0.34) RXRARXRGARICMTCYP11B2
SCHEMBL19909449 0.93 KIF11 (0.41) KIF11EPHX2S1PR1S1PR3PSEN1
SCHEMBL19918017 0.92 RXRA (0.35) KIF11RXRARXRGARICMT
SCHEMBL19912547 0.92 AR (0.34) KIF11RXRARXRGARICMT
SCHEMBL19913189 0.90 KIF11 (0.37) KIF11EPHX2DHODHS1PR1S1PR3
SCHEMBL19912541 0.90 AR (0.40) KIF11RXRARXRGARICMT
SCHEMBL19909064 0.89 NR4A2 (0.34) AAK1
SCHEMBL19903523 0.88 KIF11 (0.37) KIF11EPHX2S1PR1S1PR3RXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180062085-A1 ORGANIC MOLECULES FOR USE IN OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO., LTD. (KR) 2018-03-01 US disclosed