Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC42BPA | Q5VT25 | 5/20 | 0.75 |
| ▸ | ROCK2 | O75116 | 18/20 | 0.69 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1987156 | 0.91 | ROCK2 (0.76) | CDC42BPAROCK2ROCK1 | |
| SCHEMBL1987576 | 0.90 | ROCK2 (0.75) | CDC42BPAROCK2ROCK1 | |
| SCHEMBL1986528 | 0.90 | ROCK2 (0.74) | CDC42BPAROCK2ROCK1 | |
| SCHEMBL12562960 | 0.88 | CDC42BPA (0.84) | CDC42BPAROCK2ROCK1 | |
| SCHEMBL1987905 | 0.88 | CDC42BPA (0.77) | CDC42BPAROCK2ROCK1 | |
| SCHEMBL1986683 | 0.85 | CDC42BPA (1.00) | CDC42BPAROCK2ROCK1 | |
| SCHEMBL1990316 | 0.85 | CDC42BPA (0.77) | CDC42BPAROCK2ROCK1 | |
| SCHEMBL12562714 | 0.85 | CDC42BPA (0.93) | CDC42BPAROCK2ROCK1 | |
| SCHEMBL12603480 | 0.83 | ROCK2 (0.80) | CDC42BPAROCK2ROCK1 | |
| SCHEMBL1984516 | 0.82 | ROCK2 (1.00) | CDC42BPAROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | US | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | ROCK1, RHOA, RHOT2 | CDC42BPA 27/4885ROCK2 4/4885ROCK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.