Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24445444 | 1.00 | CYP2D6 (0.66) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL24445406 | 0.98 | CYP2D6 (0.68) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL26194821 | 0.93 | CYP2D6 (0.69) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL19916130 | 0.92 | CYP2D6 (0.59) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL19916122 | 0.92 | CYP2D6 (0.59) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL24445402 | 0.90 | CYP2D6 (0.58) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL19937782 | 0.90 | SMN1; SMN2 (0.62) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL19937883 | 0.88 | CYP2D6 (0.56) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL26194024 | 0.88 | CYP2D6 (0.63) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL22065486 | 0.88 | CYP2D6 (0.56) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3507284-B1 | BIARYL COMPOUNDS USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2022-05-25 | — | — | EP | disclosed |
| WO-2018044963-A1 | BIARYL COMPOUNDS USEFUL AS IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-08 | — | — | WO | disclosed |
| US-20180057455-A1 | COMPOUNDS USEFUL AS IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2018-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180057455-A1 | COMPOUNDS USEFUL AS IMMUNOMODULATORS | CD74, HLA-DRB1, CD47 | CYP2D6 1989/4885CYP2C19 4166/4885ALDH1A1 1130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.