Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD5 | P21918 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18761087 | 0.91 | ALDH1A1 (0.58) | CYP2D6CYP2C19ALDH1A1L3MBTL1HTT | |
| SCHEMBL24445406 | 0.89 | CYP2D6 (0.68) | CYP2D6CYP2C19ALDH1A1L3MBTL1HTT | |
| SCHEMBL19916129 | 0.88 | CYP2D6 (0.66) | CYP2D6CYP2C19ALDH1A1L3MBTL1HTT | |
| SCHEMBL24445444 | 0.88 | CYP2D6 (0.66) | CYP2D6CYP2C19ALDH1A1L3MBTL1HTT | |
| SCHEMBL24445402 | 0.87 | CYP2D6 (0.58) | CYP2D6CYP2C19ALDH1A1L3MBTL1HTT | |
| SCHEMBL26194821 | 0.84 | CYP2D6 (0.69) | CYP2D6CYP2C19ALDH1A1L3MBTL1HTT | |
| SCHEMBL20523339 | 0.84 | CD274 (0.53) | ALDH1A1KDM4EKMT2AMEN1HRH1 | |
| SCHEMBL30254987 | 0.84 | CD274 (0.53) | ALDH1A1KDM4EKMT2AMEN1HRH1 | |
| SCHEMBL20522859 | 0.84 | CD274 (0.53) | ALDH1A1KDM4EKMT2AMEN1HRH1 | |
| SCHEMBL19916130 | 0.83 | CYP2D6 (0.59) | CYP2D6CYP2C19ALDH1A1L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601258-B1 | SUBSTITUTED ISOQUIONLINE DERIVATIVES AS IMMUNOMUDULATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-30 | — | — | EP | disclosed |
| US-11046675-B2 | Substituted isoquionline derivatives as immunomudulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-06-29 | — | — | US | disclosed |
| US-20200181125-A1 | SUBSTITUTED ISOQUIONLINE DERIVATIVES AS IMMUNOMUDULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200181125-A1 | SUBSTITUTED ISOQUIONLINE DERIVATIVES AS IMMUNOMUDULATORS | CD74, HLA-DRB1, ICOS | CYP2D6 990/4885CYP2C19 3133/4885ALDH1A1 1196/4885 |
| US-11046675-B2 | Substituted isoquionline derivatives as immunomudulators | CD74, HLA-DRB1, ICOS | CYP2D6 990/4885CYP2C19 3133/4885ALDH1A1 1196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.