Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.53 |
| ▸ | RAF1 | P04049 | 2/20 | 0.50 |
| ▸ | KCNJ6 | P48051 | 6/20 | 0.49 |
| ▸ | KCNJ3 | P48549 | 6/20 | 0.49 |
| ▸ | KCNJ5 | P48544 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1013255 | 0.83 | MAPK13 (0.56) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL31324294 | 0.77 | MAPT (0.74) | ALDH1A1SMN1; SMN2MAPTPOLBKMT2A | |
| SCHEMBL15484911 | 0.75 | KCNJ6 (0.70) | MAPK14MAPK13MAPK12MAPK11KCNJ6 | |
| SCHEMBL4695418 | 0.74 | BRAF (0.56) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL15720178 | 0.73 | CDK8 (0.67) | MAPK14MAPK13MAPK12MAPK11KCNJ6 | |
| SCHEMBL1016466 | 0.73 | LMNA (0.67) | ALDH1A1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL1011730 | 0.73 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL15490413 | 0.72 | KCNJ6 (0.65) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL15485142 | 0.71 | MAPK14 (0.77) | MAPK14MAPK13MAPK12MAPK11GAA | |
| SCHEMBL4052022 | 0.70 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268623-B9 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORP (US) | 2018-02-28 | — | — | EP | disclosed |