Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 3/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20109775 | 0.91 | EGLN1 (0.62) | EGLN1THRATHRB | |
| SCHEMBL19895189 | 0.83 | MAPT (0.47) | MEN1KMT2AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL22369521 | 0.79 | EGLN1 (0.51) | EGLN1MEN1KMT2AEGLN2 | |
| SCHEMBL20109769 | 0.79 | EGLN1 (0.60) | EGLN1THRATHRBEGLN2 | |
| SCHEMBL19917277 | 0.78 | EGLN1 (0.61) | EGLN1KDM4ELMNATHRATHRB | |
| SCHEMBL18121919 | 0.78 | FTO (0.53) | EGLN1MEN1KMT2AKDM4EEGLN2 | |
| SCHEMBL20109767 | 0.76 | EGLN1 (0.57) | EGLN1LMNATHRATHRB | |
| SCHEMBL20109771 | 0.76 | EGLN1 (0.62) | EGLN1EGLN2 | |
| SCHEMBL20109766 | 0.76 | EGLN1 (0.61) | EGLN1THRATHRB | |
| SCHEMBL19917243 | 0.76 | EGLN1 (0.52) | EGLN1THRATHRBEGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3287456-A1 | COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYL OR HETEROARYL, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | Shenyang Sunshine Pharmaceutical Co., Ltd. (CN) | 2018-02-28 | — | — | EP | disclosed |