Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 4/20 | 0.36 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069527 | 1.00 | CTSK (0.44) | CTSKCA1CA2RETHSD11B1 | |
| SCHEMBL12135069 | 1.00 | CTSK (0.44) | CTSKCA1CA2RETHSD11B1 | |
| SCHEMBL24970601 | 0.89 | CTSK (0.44) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL3128871 | 0.83 | CTSK (0.42) | CTSKCA1CA2RETHSD11B1 | |
| SCHEMBL3548228 | 0.83 | CTSK (0.42) | CTSKCA1CA2RETHSD11B1 | |
| SCHEMBL19465291 | 0.82 | CTSK (0.46) | CTSKCA1CA2RETHSD11B1 | |
| SCHEMBL20070141 | 0.82 | CTSK (0.46) | CTSKCA1CA2RETHSD11B1 | |
| SCHEMBL24854857 | 0.82 | CTSK (0.46) | CTSKCA1CA2RETHSD11B1 | |
| SCHEMBL20147483 | 0.82 | CTSK (0.41) | CTSKCA1CA2RETHSD11B1 | |
| SCHEMBL28826192 | 0.81 | SSTR4 (0.47) | CTSKCA1CA2HSD11B1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367800-B9 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | IPHARMA H K LTD (HK) | 2021-10-20 | — | — | EP | disclosed |
| EP-2367800-B1 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | BOEHRINGER INGELHEIM INT (DE) | 2018-02-28 | — | — | EP | disclosed |