⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29952127 | 0.70 | — | — | |
| SCHEMBL1989539 | 0.69 | ACKR3 (0.40) | — | |
| SCHEMBL1989383 | 0.68 | NFE2L2 (0.41) | — | |
| SCHEMBL14562372 | 0.68 | HTR2A (0.36) | — | |
| SCHEMBL1990765 | 0.67 | NFE2L2 (0.37) | — | |
| SCHEMBL2814972 | 0.66 | ACKR3 (0.58) | — | |
| SCHEMBL31447858 | 0.65 | MAPT (0.47) | — | |
| SCHEMBL1995505 | 0.64 | KDM4E (0.40) | — | |
| SCHEMBL2813168 | 0.64 | L3MBTL1 (0.47) | — | |
| SCHEMBL1991893 | 0.62 | CDK4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516440-B1 | BRIDGEHEAD AMINE RING-FUSED INDOLES AND INDOLINES USEFUL TO TREAT NEURODEGENERATIVE AND NEUROPSYCHIATRIC DISORDERS | ABBVIE INC (US) | 2014-07-23 | — | — | EP | disclosed |
| US-8524703-B2 | Bridgehead amine ring-fused indoles and indolines | ABBVIE INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-20110152248-A1 | BRIDGEHEAD AMINE RING-FUSED INDOLES AND INDOLINES | ABBOTT LABORATORIES (US) | 2011-06-23 | — | — | US | disclosed |