Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 16/20 | 0.66 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.66 |
| ▸ | MIF | P14174 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9621792 | 0.86 | P4HTM (0.61) | P4HTMP4HA1MIFKDM4EL3MBTL1 | |
| SCHEMBL23625508 | 0.81 | P4HTM (0.42) | P4HTMP4HA1MIFKDM4EL3MBTL1 | |
| Pyridine-2,5-Dicarboxylic Acid SCHEMBL70231 | 0.80 | P4HTM (1.00) | P4HTMP4HA1MIFKDM4EL3MBTL1 | |
| Pyridine-2,5-Dicarboxylic Acid SCHEMBL29363410 | 0.80 | P4HTM (1.00) | P4HTMP4HA1MIFKDM4EL3MBTL1 | |
| SCHEMBL30786512 | 0.79 | KDM4E (0.56) | P4HTMP4HA1MIFKDM4EL3MBTL1 | |
| SCHEMBL23149647 | 0.79 | KDM4E (0.56) | P4HTMP4HA1MIFKDM4EL3MBTL1 | |
| SCHEMBL1585449 | 0.79 | P4HTM (0.73) | P4HTMP4HA1MIFKDM4EL3MBTL1 | |
| Pyridine-2,5-Dicarboxylic Acid SCHEMBL11489139 | 0.78 | P4HTM (0.95) | P4HTMP4HA1MIFKDM4EL3MBTL1 | |
| Pyridine-2,5-Dicarboxylic Acid SCHEMBL21173963 | 0.78 | P4HTM (0.95) | P4HTMP4HA1MIFKDM4EL3MBTL1 | |
| Pyridine-2,5-Dicarboxylic Acid SCHEMBL9341728 | 0.78 | P4HTM (0.95) | P4HTMP4HA1MIFKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180057505-A1 | BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED | 2018-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180057505-A1 | BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | F2RL1, PARP12, TFPI2 | P4HTM 1576/4885P4HA1 1571/4885MIF 2204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.