Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 15/20 | 0.61 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.61 |
| ▸ | MIF | P14174 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276744 | 0.86 | P4HA1 (0.61) | P4HTMP4HA1MIFL3MBTL1KDM4E | |
| SCHEMBL19919862 | 0.86 | P4HTM (0.66) | P4HTMP4HA1MIFL3MBTL1KDM4E | |
| SCHEMBL27386679 | 0.79 | HSD17B3 (0.53) | L3MBTL1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL11899972 | 0.77 | NAPRT (0.56) | L3MBTL1ALDH1A1MEN1LMNAMAPT | |
| SCHEMBL13838594 | 0.77 | SMN1; SMN2 (0.56) | L3MBTL1HPGDSMN1; SMN2HSD17B3 | |
| SCHEMBL568662 | 0.77 | HSD17B3 (0.52) | L3MBTL1HPGDSMN1; SMN2HSD17B3 | |
| Pyridine-2,5-Dicarboxylic Acid SCHEMBL70231 | 0.77 | P4HTM (1.00) | P4HTMP4HA1MIFL3MBTL1KDM4E | |
| Pyridine-2,5-Dicarboxylic Acid SCHEMBL29363410 | 0.77 | P4HTM (1.00) | P4HTMP4HA1MIFL3MBTL1KDM4E | |
| SCHEMBL27525392 | 0.77 | P4HTM (0.58) | P4HTMP4HA1MIFL3MBTL1KDM4E | |
| SCHEMBL23149647 | 0.76 | KDM4E (0.56) | P4HTMP4HA1MIFL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260814-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-02-05 | — | — | EP | disclosed |
| US-4992459-A | Hypotensive agents, antiulcer agents | SMITHKLINE BEECHAM CORPORATION (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0288488-A4 | DOPAMINE- -HYDROXYLASE INHIBITORS | — | 1990-09-12 | — | — | EP | disclosed |
| US-4935438-A | Dopamine-β-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1990-06-19 | — | — | US | disclosed |
| EP-0371733-A2 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0371732-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0371730-A1 | Dopamine-B-Hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-06 | — | — | EP | disclosed |
| US-4912226-A | A 1-(benyzlsubstituted-),2-((1,3-dioneisoindolin-2-yl)alkyl thio-)imidazole | SMITHKLINE BECKMAN CORPORATION (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0359505-A1 | Dopamine-beta hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1990-03-21 | — | — | EP | disclosed |
| US-4882348-A | HYPOTENSIVE AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-11-21 | — | — | US | disclosed |
| EP-0250264-A1 | Irreversible dopamine-Beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1987-12-23 | — | — | EP | disclosed |
| CN-87103808-A | The dopamine-inhibitor | — | 1987-12-09 | — | — | CN | disclosed |
| EP-0246888-A2 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1987-11-25 | — | — | EP | disclosed |
| EP-0244956-A1 | Ester prodrugs of dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1987-11-11 | — | — | EP | disclosed |
| EP-0225718-A2 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1987-06-16 | — | — | EP | disclosed |
| EP-0219961-A1 | Irreversible dopamine-B-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1987-04-29 | — | — | EP | disclosed |
| EP-0214740-A2 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1987-03-18 | — | — | EP | disclosed |
| US-4634711-A | ENZYME INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1987-01-06 | — | — | US | disclosed |
| US-4628059-A | TRIAZOLES | SMITHKLEIN BECKMAN CORPORATION (US) | 1986-12-09 | — | — | US | disclosed |
| US-4532331-A | 1-Benzyl-2-aminomethyl imidazole derivatives | SMITHKLINE BECKMAN CORPORATION (US) | 1985-07-30 | — | — | US | disclosed |