Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.86 |
| ▸ | INSR | P06213 | 5/20 | 0.65 |
| ▸ | IGF1R | P08069 | 5/20 | 0.65 |
| ▸ | TTK | P33981 | 4/20 | 0.65 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.65 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.65 |
| ▸ | FES | P07332 | 3/20 | 0.65 |
| ▸ | FLT3 | P36888 | 3/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.65 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.65 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.65 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.65 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.65 |
| ▸ | PLK4 | O00444 | 2/20 | 0.65 |
| ▸ | GAK | O14976 | 2/20 | 0.65 |
| ▸ | ERN1 | O75460 | 2/20 | 0.65 |
| ▸ | STK10 | O94804 | 2/20 | 0.65 |
| ▸ | ABL1 | P00519 | 2/20 | 0.65 |
| ▸ | EGFR | P00533 | 2/20 | 0.65 |
| ▸ | LCK | P06239 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14866202 | 0.82 | ALK (0.85) | ALKINSRIGF1RTTKPTK2 | |
| SCHEMBL19921104 | 0.82 | ALK (0.78) | ALKINSRIGF1RTTKPTK2 | |
| SCHEMBL12892781 | 0.82 | ALK (0.91) | ALKINSRIGF1RTTKPTK2 | |
| SCHEMBL21150935 | 0.81 | ALK (0.82) | ALKINSRIGF1RTTKPTK2 | |
| SCHEMBL19921103 | 0.81 | ALK (0.78) | ALKINSRIGF1RTTKPTK2 | |
| SCHEMBL14866223 | 0.81 | ALK (0.78) | ALKINSRIGF1RTTKPTK2 | |
| SCHEMBL26380289 | 0.80 | ALK (0.57) | ALKINSRIGF1RTTKPTK2 | |
| SCHEMBL14866161 | 0.79 | ALK (0.83) | ALKINSRIGF1RTTKPTK2 | |
| SCHEMBL14866426 | 0.79 | ALK (0.80) | ALKINSRIGF1RTTKPTK2 | |
| SCHEMBL14866424 | 0.79 | ALK (0.78) | ALKINSRIGF1RTTKPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | claimed |
| EP-3290420-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Xiamen University (CN) | 2018-03-07 | — | — | EP | claimed |