Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 12/20 | 0.78 |
| ▸ | INSR | P06213 | 4/20 | 0.59 |
| ▸ | IGF1R | P08069 | 3/20 | 0.59 |
| ▸ | ROS1 | P08922 | 3/20 | 0.59 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.59 |
| ▸ | PLK4 | O00444 | 2/20 | 0.59 |
| ▸ | GAK | O14976 | 2/20 | 0.59 |
| ▸ | ERN1 | O75460 | 2/20 | 0.59 |
| ▸ | STK10 | O94804 | 2/20 | 0.59 |
| ▸ | ABL1 | P00519 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | LCK | P06239 | 2/20 | 0.59 |
| ▸ | FYN | P06241 | 2/20 | 0.59 |
| ▸ | FES | P07332 | 2/20 | 0.59 |
| ▸ | YES1 | P07947 | 2/20 | 0.59 |
| ▸ | HCK | P08631 | 2/20 | 0.59 |
| ▸ | FER | P16591 | 2/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.59 |
| ▸ | LTK | P29376 | 2/20 | 0.59 |
| ▸ | FLT3 | P36888 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21150135 | 0.89 | ALK (0.64) | ALKINSRIGF1RROS1BMPR1B | |
| SCHEMBL3956400 | 0.86 | ALK (0.62) | ALKINSRIGF1RROS1BMPR1B | |
| SCHEMBL18018889 | 0.83 | ALK (0.60) | ALKINSRIGF1RROS1BMPR1B | |
| SCHEMBL21150898 | 0.82 | ALK (0.56) | ALKINSRIGF1RROS1BMPR1B | |
| SCHEMBL19921077 | 0.82 | MAPK7 (0.54) | ALKINSRIGF1RROS1BMPR1B | |
| SCHEMBL18018798 | 0.81 | TTK (0.54) | ALKINSRIGF1RROS1BMPR1B | |
| SCHEMBL19921082 | 0.81 | ALK (0.86) | ALKINSRIGF1RROS1BMPR1B | |
| SCHEMBL13906274 | 0.80 | ALK (0.56) | ALKINSRIGF1RROS1BMPR1B | |
| SCHEMBL4047900 | 0.80 | FES (0.66) | ALKINSRIGF1RROS1BMPR1B | |
| SCHEMBL18018792 | 0.80 | LRRK2 (0.65) | ALKINSRIGF1RROS1BMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | claimed |
| EP-3290420-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Xiamen University (CN) | 2018-03-07 | — | — | EP | claimed |