Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.56 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.50 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19921185 | 0.94 | PTK2 (0.59) | EGFRPTK2 | |
| SCHEMBL19921124 | 0.88 | ALK (0.56) | EGFRPTK2 | |
| SCHEMBL19921170 | 0.85 | EGFR (0.55) | EGFRPTK2 | |
| SCHEMBL19921168 | 0.82 | ALK (0.65) | EGFRPTK2NUAK1 | |
| SCHEMBL19921118 | 0.81 | ALK (0.62) | EGFRPTK2 | |
| SCHEMBL19921152 | 0.80 | EGFR (0.50) | EGFRPTK2NUAK1NUAK2 | |
| SCHEMBL19921145 | 0.80 | DCLK1 (0.43) | EGFRPTK2 | |
| SCHEMBL21099503 | 0.77 | ALK (0.60) | EGFRPTK2 | |
| SCHEMBL19921100 | 0.77 | ALK (0.52) | EGFRPTK2 | |
| SCHEMBL20546932 | 0.76 | ALK (0.65) | EGFRPTK2NUAK1NUAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | claimed |
| US-20180312508-A1 | PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF | XIAMEN UNIVERSITY (CN) | 2018-11-01 | — | — | US | claimed |
| EP-3290420-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Xiamen University (CN) | 2018-03-07 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312508-A1 | PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF | TPMT, DHPS, TYMP | EGFR 3364/4885PTK2 4325/4885NUAK1 3158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.