Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 9/20 | 0.52 |
| ▸ | JAK2 | O60674 | 8/20 | 0.52 |
| ▸ | JAK3 | P52333 | 8/20 | 0.52 |
| ▸ | BRD4 | O60885 | 7/20 | 0.46 |
| ▸ | STAT6 | P42226 | 2/20 | 0.45 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19921146 | 0.91 | PTK2 (0.62) | PTK2JAK2JAK3BRD4STAT6 | |
| SCHEMBL19921119 | 0.91 | PTK2 (0.46) | PTK2JAK2JAK3BRD4STAT6 | |
| SCHEMBL19921089 | 0.87 | AXL (0.53) | PTK2JAK2JAK3BRD4BRD2 | |
| SCHEMBL19921107 | 0.86 | ALK (0.57) | PTK2JAK2JAK3AXLNEK2 | |
| SCHEMBL19867342 | 0.86 | BRD4 (0.53) | PTK2JAK2JAK3BRD4STAT6 | |
| SCHEMBL19921147 | 0.85 | PDE5A (0.47) | PTK2PDE5A | |
| SCHEMBL19921166 | 0.82 | STAT6 (0.53) | PTK2JAK2JAK3BRD4STAT6 | |
| SCHEMBL19921133 | 0.82 | ALK (0.65) | PTK2JAK2JAK3AXLNEK2 | |
| SCHEMBL19921080 | 0.81 | JAK2 (0.43) | PTK2JAK2JAK3BRD4STAT6 | |
| SCHEMBL19921112 | 0.79 | PTK2 (0.62) | PTK2JAK2JAK3BRD4BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | claimed |
| EP-3290420-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Xiamen University (CN) | 2018-03-07 | — | — | EP | claimed |