Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 4/20 | 0.53 |
| ▸ | JAK3 | P52333 | 10/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 10/20 | 0.51 |
| ▸ | JAK2 | O60674 | 9/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19921119 | 0.92 | PTK2 (0.46) | STAT6JAK3PTK2JAK2IRAK4 | |
| SCHEMBL19921146 | 0.90 | PTK2 (0.62) | STAT6JAK3PTK2JAK2BRD4 | |
| SCHEMBL19921167 | 0.88 | PTK2 (0.51) | JAK3PTK2JAK2IRAK4BRD4 | |
| SCHEMBL19921122 | 0.85 | PLK4 (0.47) | STAT6JAK3PTK2JAK2IRAK4 | |
| SCHEMBL20547121 | 0.85 | STAT6 (0.51) | STAT6JAK3JAK2IRAK4DCLK1 | |
| SCHEMBL19867315 | 0.84 | IRAK4 (0.56) | STAT6JAK3PTK2JAK2IRAK4 | |
| SCHEMBL19921070 | 0.83 | STAT6 (0.43) | STAT6JAK3JAK2IRAK4DCLK1 | |
| SCHEMBL19921195 | 0.82 | STAT6 (0.46) | STAT6JAK3JAK2IRAK4 | |
| SCHEMBL19921188 | 0.82 | PTK2 (0.52) | STAT6JAK3PTK2JAK2BRD4 | |
| SCHEMBL19921154 | 0.81 | PDE5A (0.49) | STAT6JAK3PTK2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | claimed |
| US-20180312508-A1 | PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF | XIAMEN UNIVERSITY (CN) | 2018-11-01 | — | — | US | claimed |
| EP-3290420-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Xiamen University (CN) | 2018-03-07 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312508-A1 | PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF | TPMT, DHPS, TYMP | STAT6 640/4885JAK3 112/4885PTK2 4325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.