Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.53 |
| ▸ | NEK2 | P51955 | 2/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.53 |
| ▸ | JAK2 | O60674 | 4/20 | 0.51 |
| ▸ | JAK3 | P52333 | 4/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.50 |
| ▸ | BRD4 | O60885 | 4/20 | 0.48 |
| ▸ | MET | P08581 | 3/20 | 0.48 |
| ▸ | INSR | P06213 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | STK25 | O00506 | 1/20 | 0.48 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | CASK | O14936 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19921112 | 0.90 | PTK2 (0.62) | AXLNEK2PTK2JAK2JAK3 | |
| SCHEMBL19921159 | 0.90 | PTK2 (0.58) | AXLNEK2PTK2JAK2JAK3 | |
| SCHEMBL19921188 | 0.87 | PTK2 (0.52) | AXLNEK2PTK2JAK2JAK3 | |
| SCHEMBL19921063 | 0.86 | ALK (0.68) | AXLNEK2PTK2JAK2JAK3 | |
| SCHEMBL19867185 | 0.85 | ALK (0.63) | AXLNEK2PTK2JAK2JAK3 | |
| SCHEMBL19921177 | 0.84 | PDE5A (0.44) | PTK2ALKMETAURKATTK | |
| SCHEMBL19921135 | 0.82 | CCNK (0.50) | AXLNEK2PTK2JAK2JAK3 | |
| SCHEMBL19921074 | 0.81 | PTK2 (0.67) | PTK2JAK2ALKMETINSR | |
| SCHEMBL19929897 | 0.81 | ALK (0.45) | PTK2ALKMETINSRDCLK1 | |
| SCHEMBL19921167 | 0.81 | PTK2 (0.51) | AXLNEK2PTK2JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | claimed |
| EP-3290420-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Xiamen University (CN) | 2018-03-07 | — | — | EP | claimed |