Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 19/20 | 1.00 |
| ▸ | MAP4K2 | Q12851 | 19/20 | 1.00 |
| ▸ | ABL1 | P00519 | 3/20 | 0.77 |
| ▸ | BMX | P51813 | 3/20 | 0.77 |
| ▸ | BCR | P11274 | 1/20 | 0.77 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.77 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.77 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.69 |
| ▸ | LCK | P06239 | 1/20 | 0.68 |
| ▸ | FES | P07332 | 1/20 | 0.68 |
| ▸ | RET | P07949 | 1/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.68 |
| ▸ | KIT | P10721 | 1/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.68 |
| ▸ | SRC | P12931 | 1/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.68 |
| ▸ | FLT1 | P17948 | 1/20 | 0.68 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.68 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.68 |
| ▸ | KDR | P35968 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19922805 | 0.94 | TNK2 (0.90) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL29750378 | 0.93 | TNK2 (0.86) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL3139197 | 0.92 | TNK2 (1.00) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL29750257 | 0.92 | TNK2 (0.84) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL19922731 | 0.91 | TNK2 (0.90) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL29750223 | 0.91 | TNK2 (0.83) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL3132265 | 0.88 | TNK2 (0.84) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL3139165 | 0.88 | TNK2 (0.89) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL29404264 | 0.88 | TNK2 (1.00) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL29875282 | 0.88 | TNK2 (1.00) | TNK2MAP4K2ABL1BMXBCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10155767-B2 | Therapeutic agent of acute myeloid leukemia containing 1,3,7-trisubstituted 3,4-dihydropyrimido[4,5-D]pyrimidine-2(1H)-one derivatives | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-12-18 | — | — | US | claimed |
| US-10155767-B2 | Therapeutic agent of acute myeloid leukemia containing 1,3,7-trisubstituted 3,4-dihydropyrimido[4,5-D]pyrimidine-2(1H)-one derivatives | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-12-18 | — | — | US | disclosed |
| US-20180065969-A1 | THERAPEUTIC AGENT OF ACUTE MYELOID LEUKEMIA CONTAINING 1,3,7-TRISUBSTITUTED 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDINE-2(1H)-ONE DERIVATIVES | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-03-08 | — | — | US | disclosed |
| US-20180065969-A1 | THERAPEUTIC AGENT OF ACUTE MYELOID LEUKEMIA CONTAINING 1,3,7-TRISUBSTITUTED 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDINE-2(1H)-ONE DERIVATIVES | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-03-08 | — | — | US | disclosed |
| US-20180065969-A1 | THERAPEUTIC AGENT OF ACUTE MYELOID LEUKEMIA CONTAINING 1,3,7-TRISUBSTITUTED 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDINE-2(1H)-ONE DERIVATIVES | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10155767-B2 | Therapeutic agent of acute myeloid leukemia containing 1,3,7-trisubstituted 3,4-dihydropyrimido[4,5-D]pyrimidine-2(1H)-one derivatives | GAK, DCK, NRAS | TNK2 38/4885MAP4K2 50/4885ABL1 206/4885 |
| US-20180065969-A1 | THERAPEUTIC AGENT OF ACUTE MYELOID LEUKEMIA CONTAINING 1,3,7-TRISUBSTITUTED 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDINE-2(1H)-ONE DERIVATIVES | GAK, DCK, NRAS | TNK2 38/4885MAP4K2 50/4885ABL1 206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.