Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 13/20 | 0.67 |
| ▸ | MAP4K2 | Q12851 | 13/20 | 0.67 |
| ▸ | LCK | P06239 | 7/20 | 0.63 |
| ▸ | ABL1 | P00519 | 2/20 | 0.61 |
| ▸ | BCR | P11274 | 1/20 | 0.61 |
| ▸ | BMX | P51813 | 1/20 | 0.61 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.61 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23045858 | 0.90 | TNK2 (0.82) | TNK2MAP4K2LCKABL1BCR | |
| SCHEMBL23045832 | 0.88 | TNK2 (0.59) | TNK2MAP4K2LCKABL1BCR | |
| SCHEMBL19865443 | 0.87 | TNK2 (0.72) | TNK2MAP4K2LCKABL1BCR | |
| SCHEMBL23666351 | 0.85 | TNK2 (0.70) | TNK2MAP4K2LCKABL1BCR | |
| SCHEMBL23045855 | 0.85 | TNK2 (0.61) | TNK2MAP4K2LCKABL1BCR | |
| SCHEMBL3144304 | 0.84 | BMX (0.53) | TNK2MAP4K2LCKABL1BCR | |
| SCHEMBL23059372 | 0.84 | TNK2 (0.79) | TNK2MAP4K2LCKABL1BCR | |
| SCHEMBL23045833 | 0.84 | TNK2 (0.69) | TNK2MAP4K2LCKABL1BCR | |
| SCHEMBL23045876 | 0.83 | TNK2 (0.80) | TNK2MAP4K2LCKABL1BCR | |
| SCHEMBL23648637 | 0.83 | TNK2 (0.70) | TNK2MAP4K2LCKABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260070913-A1 | 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | KOREA INST SCI & TECH (KR) | 2026-03-12 | — | — | US | disclosed |
| US-20230103742-A1 | 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2023-04-06 | — | — | US | disclosed |
| EP-4092029-A1 | 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | Korea Institute of Science and Technology (KR) | 2022-11-23 | — | — | EP | disclosed |
| WO-2021145520-A1 | 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 한국과학기술연구원 | 2021-07-22 | — | — | WO | disclosed |
| US-10059717-B2 | Urea compounds containing 3,4-dihydropyrimido[4,5-D]pyrimidin-2(1H)-one skeleton as protein kinase inhibitors | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-08-28 | — | — | US | disclosed |
| US-20180065970-A1 | UREA COMPOUNDS CONTAINING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE SKELETON AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-03-08 | — | — | US | disclosed |
| US-20180065970-A1 | UREA COMPOUNDS CONTAINING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE SKELETON AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230103742-A1 | 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | HASPIN, WEE2, CDK7 | TNK2 22/4885MAP4K2 36/4885LCK 229/4885 |
| US-10059717-B2 | Urea compounds containing 3,4-dihydropyrimido[4,5-D]pyrimidin-2(1H)-one skeleton as protein kinase inhibitors | MAP4K2, CMPK1, MTOR | TNK2 230/4885MAP4K2 1/4885LCK 405/4885 |
| US-20260070913-A1 | 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | CSNK1A1, CKS1B, HGFAC | TNK2 28/4885MAP4K2 165/4885LCK 626/4885 |
| US-20180065970-A1 | UREA COMPOUNDS CONTAINING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE SKELETON AS PROTEIN KINASE INHIBITORS | MAP4K2, CMPK1, MTOR | TNK2 230/4885MAP4K2 1/4885LCK 405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.