Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | ALDH5A1 | P51649 | 3/20 | 0.47 |
| ▸ | ABAT | P80404 | 3/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.47 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28050177 | 0.84 | KDM4E (0.57) | KDM4EPTGS2RAB9AALDH1A1ALDH5A1 | |
| SCHEMBL13257341 | 0.83 | KDM4E (0.61) | KDM4EPTGS2RAB9AALDH1A1ALDH5A1 | |
| SCHEMBL18714281 | 0.83 | KDM4E (0.61) | KDM4EPTGS2RAB9AALDH1A1ALDH5A1 | |
| SCHEMBL3429786 | 0.80 | KDM4E (0.57) | KDM4EPTGS2RAB9AALDH1A1ALDH5A1 | |
| SCHEMBL31256694 | 0.80 | KDM4E (0.57) | KDM4EPTGS2RAB9AALDH1A1ALDH5A1 | |
| SCHEMBL14456529 | 0.78 | RAB9A (0.55) | KDM4EPTGS2RAB9AALDH1A1ALDH5A1 | |
| SCHEMBL31136826 | 0.76 | ALDH1A1 (0.45) | KDM4EPTGS2RAB9AALDH1A1TDP1 | |
| SCHEMBL14396702 | 0.76 | ALDH1A1 (0.38) | KDM4EPTGS2RAB9AALDH1A1ALDH5A1 | |
| SCHEMBL7245766 | 0.76 | ALDH1A1 (0.56) | KDM4EPTGS2RAB9AALDH1A1ALDH5A1 | |
| SCHEMBL13787395 | 0.76 | KDM4E (0.52) | KDM4EPTGS2RAB9AALDH1A1ALDH5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018045142-A1 | IMMUNE CHECKPOINT INHIBITORS, COMPOSITIONS AND METHODS THEREOF | POLARIS PHARMACEUTICALS, INC. (US) | 2018-03-08 | — | — | WO | disclosed |
| US-20180065917-A1 | IMMUNE CHECKPOINT INHIBITORS, COMPOSITIONS AND METHODS THEREOF | POLARIS PHARMACEUTICALS, INC. (JP) | 2018-03-08 | — | — | US | disclosed |
| US-20180065917-A1 | IMMUNE CHECKPOINT INHIBITORS, COMPOSITIONS AND METHODS THEREOF | POLARIS PHARMACEUTICALS, INC. (JP) | 2018-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180065917-A1 | IMMUNE CHECKPOINT INHIBITORS, COMPOSITIONS AND METHODS THEREOF | CD274, PDCD1, PDCD1LG2 | KDM4E 1808/4885PTGS2 4671/4885RAB9A 2168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.