Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Sulfoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1940530 | 0.85 | TRPA1 (0.40) | TRPA1ALDH1A1TSHRCES2CES1 | |
| SCHEMBL131361 | 0.80 | ALDH1A1 (0.67) | TRPA1ALDH1A1TSHRCES2CES1 | |
| Trimethylammonium SCHEMBL3792932 | 0.75 | ALDH1A1 (0.53) | TRPA1ALDH1A1TSHRCES2CES1 | |
| SCHEMBL19249949 | 0.74 | TRPA1 (0.36) | TRPA1ALDH1A1TSHRCES2CES1 | |
| SCHEMBL4617192 | 0.74 | IDO1 (0.38) | TRPA1ALDH1A1TSHRCES2CES1 | |
| SCHEMBL13667748 | 0.74 | TRPA1 (0.40) | TRPA1ALDH1A1TSHRCES2CES1 | |
| SCHEMBL153348 | 0.73 | ALDH1A1 (0.50) | TRPA1ALDH1A1TSHRCES2CES1 | |
| SCHEMBL121442 | 0.73 | — | — | |
| SCHEMBL5734655 | 0.73 | IDO1 (0.52) | TRPA1ALDH1A1TSHRCES2CES1 | |
| SCHEMBL18552646 | 0.72 | TRPA1 (0.43) | TRPA1ALDH1A1TSHRCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10239990-B2 | Isatin copolymers having intrinsic microporosity | DOW GLOBAL TECHNOLOGIES LLC | 2019-03-26 | — | — | US | disclosed |
| US-20180066103-A1 | ISATIN COPOLYMERS HAVING INTRINSIC MICROPOROSITY | DOW GLOBAL TECHNOLOGIES LLC (US) | 2018-03-08 | — | — | US | disclosed |