⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10801362 | 0.80 | — | — | |
| SCHEMBL10435646 | 0.77 | — | — | |
| SCHEMBL2940889 | 0.68 | TRPA1 (0.44) | — | |
| SCHEMBL161873 | 0.59 | — | — | |
| Methane SCHEMBL11216534 | 0.59 | — | — | |
| SCHEMBL3862434 | 0.59 | — | — | |
| SCHEMBL999460 | 0.58 | — | — | |
| Hydrochloric Acid SCHEMBL6456940 | 0.58 | — | — | |
| SCHEMBL121541 | 0.57 | — | — | |
| SCHEMBL7637492 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504214-A1 | FUSED TRICYCLIC PYRIDAZINONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | Novartis AG (CH) | 2019-07-03 | — | — | EP | claimed |
| WO-2018042303-A1 | FUSED TRICYCLIC PYRIDAZINONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2018-03-08 | — | — | WO | claimed |
| US-20250011334-A1 | FUSED TRICYCLIC PYRIDAZINONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2025-01-09 | — | — | US | disclosed |
| CN-110128288-B | Preparation method of amino-substituted cyclopentane alkyl formate derivative | 浙江九洲药业股份有限公司 | 2023-07-28 | — | — | CN | disclosed |
| CN-113683614-A | Fused tricyclic pyridazinone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2021-11-23 | — | — | CN | disclosed |
| CN-109863151-B | Fused tricyclic pyridazinone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2021-09-10 | — | — | CN | disclosed |
| CN-111801333-A | 10- (di (phenyl) methyl) -4-hydroxy-8, 9,9a, 10-tetrahydro-7H-pyrrolo [1',2':4,5] pyrazino [1,2-b ] pyridazine-3, 5-dione derivatives and related compounds as inhibitors of orthomyxovirus replication for the treatment of influenza | 诺华股份有限公司 | 2020-10-20 | — | — | CN | disclosed |
| EP-3504214-A1 | FUSED TRICYCLIC PYRIDAZINONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | Novartis AG (CH) | 2019-07-03 | — | — | EP | disclosed |
| WO-2018042303-A1 | FUSED TRICYCLIC PYRIDAZINONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2018-03-08 | — | — | WO | disclosed |