SCHEMBL19927473

SCHEMBL19927473

CC(C)(C)[Si](C)(C)O[C@@H]1[C@H](N)[C@@H](CNC(=S)N[C@H]2[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](n3cnc4c(NC(=O)c5ccccc5)ncnc43)O[C@@H]2CN=[N+]=[N-])O[C@H]1n1cnc2c(NC(=O)c3ccccc3)ncnc21

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ PRMT6 Q96LA8 1/20 0.43
▸ BMPR1B O00238 1/20 0.39
▸ P2RY12 Q9H244 8/20 0.38
▸ AHCY P23526 1/20 0.37
▸ ADORA1 P30542 2/20 0.36
▸ P2RY2 P41231 1/20 0.36
▸ P2RY1 P47900 1/20 0.36
▸ P2RY6 Q15077 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19927513 0.91 PRMT6 (0.41) PRMT6BMPR1BP2RY12ADORA1P2RY2
SCHEMBL19927469 0.90 PRMT6 (0.49) PRMT6BMPR1BP2RY12AHCYADORA1
SCHEMBL19927373 0.88 PRMT6 (0.39) PRMT6BMPR1BP2RY12
SCHEMBL30445813 0.85 PRMT6 (0.49) PRMT6BMPR1BP2RY12AHCYADORA1
SCHEMBL22206837 0.85 PRMT6 (0.49) PRMT6BMPR1BP2RY12AHCYADORA1
SCHEMBL19927301 0.82 PRMT6 (0.46) PRMT6BMPR1BP2RY12AHCYADORA1
SCHEMBL19927545 0.81 PRMT6 (0.43) PRMT6P2RY12ADORA1P2RY2P2RY1
SCHEMBL19128447 0.81 PRMT6 (0.51) PRMT6P2RY12ADORA1
SCHEMBL19128052 0.81 PRMT6 (0.51) PRMT6P2RY12ADORA1
SCHEMBL19128087 0.81 PRMT6 (0.51) PRMT6P2RY12ADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190345191-A1 CYCLIC DINUCLEOTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH STING (STIMULATOR OF INTERFERON GENES) ACTIVITY INNATE TUMOR IMMUNITY INC (US) 2019-11-14 — — US disclosed
WO-2018045204-A1 CYCLIC DINUCLEOTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH STING (STIMULATOR OF INTERFERON GENES) ACTIVITY IFM THERAPEUTICS, INC (US) 2018-03-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190345191-A1 CYCLIC DINUCLEOTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH STING (STIMULATOR OF INTERFERON GENES) ACTIVITY STING1, CGAS, IRF3 PRMT6 3041/4885BMPR1B 1686/4885P2RY12 235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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