Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.69 |
| ▸ | GAA | P10253 | 3/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | ATM | Q13315 | 1/20 | 0.69 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.63 |
| ▸ | HPGD | P15428 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 6/20 | 0.60 |
| ▸ | RECQL | P46063 | 4/20 | 0.60 |
| ▸ | BLM | P54132 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | APEX1 | P27695 | 2/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.60 |
| ▸ | RGS12 | O14924 | 2/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32688162 | 0.90 | MAPT (0.66) | MAPTALDH1A1GAAHTTATM | |
| SCHEMBL32688099 | 0.85 | MAPT (0.57) | MAPTALDH1A1GAAHTTATM | |
| SCHEMBL32688435 | 0.81 | MAPT (0.70) | MAPTALDH1A1GAAHTTATM | |
| SCHEMBL4879813 | 0.81 | MAPT (0.70) | MAPTALDH1A1GAAHTTATM | |
| SCHEMBL4878079 | 0.81 | MAPT (0.70) | MAPTALDH1A1GAAHTTATM | |
| SCHEMBL4879772 | 0.81 | MAPT (0.70) | MAPTALDH1A1GAAHTTATM | |
| SCHEMBL24990617 | 0.81 | MCL1 (0.68) | MAPTALDH1A1GAAHTTATM | |
| SCHEMBL1692376 | 0.81 | MCL1 (1.00) | MAPTALDH1A1GAAMCL1TDP1 | |
| SCHEMBL1692375 | 0.81 | MCL1 (1.00) | MAPTALDH1A1GAAMCL1TDP1 | |
| SCHEMBL1388543 | 0.80 | MAPT (0.63) | MAPTALDH1A1GAAHTTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883577-B1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | UNIV CASE WESTERN RESERVE (US) | 2026-04-08 | — | — | EP | disclosed |
| US-12336982-B2 | Compositions and methods of modulating short-chain dehydrogenase activity | RODEO THERAPEUTICS CORPORATION (US) | 2025-06-24 | — | — | US | disclosed |
| CN-113507931-B | Compositions and methods for modulating short-chain dehydrogenase activity | 卡斯西部储备大学 | 2025-05-27 | — | — | CN | disclosed |
| US-20250161277-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2025-05-22 | — | — | US | disclosed |
| US-20230039604-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | RODEO THERAPEUTICS CORPORATION | 2023-02-09 | — | — | US | disclosed |
| US-20230039604-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | RODEO THERAPEUTICS CORPORATION | 2023-02-09 | — | — | US | disclosed |
| CN-113507931-A | Compositions and methods for modulating short-chain dehydrogenase activity | 卡斯西部储备大学 | 2021-10-15 | — | — | CN | disclosed |
| EP-3883577-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | CASE WESTERN RESERVE UNIVERSITY (US) | 2021-09-29 | — | — | EP | disclosed |
| US-9908893-B2 | Thieno [2,3-b] pyridines as multidrug resistance modulators | LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2018-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250161277-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | HPGD, GCDH, HPGDS | MAPT 4066/4885ALDH1A1 126/4885GAA 420/4885 |
| US-12336982-B2 | Compositions and methods of modulating short-chain dehydrogenase activity | HPGD, GCDH, HPGDS | MAPT 4066/4885ALDH1A1 126/4885GAA 420/4885 |
| US-20230039604-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | HPGD, GCDH, HPGDS | MAPT 4066/4885ALDH1A1 126/4885GAA 420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.