Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | LDHB | P07195 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19928394 | 0.87 | LDHA (0.46) | LDHALDHBCAMK2D | |
| SCHEMBL20256988 | 0.86 | SMN1; SMN2 (0.46) | SMN1; SMN2RAB9ANPC1TP53LDHA | |
| SCHEMBL20256987 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2RAB9ANPC1TP53LDHA | |
| SCHEMBL19928396 | 0.85 | LDHA (0.46) | SMN1; SMN2RAB9ANPC1TP53LDHA | |
| SCHEMBL15131383 | 0.82 | SMN1; SMN2 (0.43) | SMN1; SMN2RAB9ANPC1TP53LDHA | |
| SCHEMBL20256989 | 0.73 | LDHA (0.46) | SMN1; SMN2RAB9ANPC1TP53LDHA | |
| SCHEMBL20256902 | 0.73 | SMN1; SMN2 (0.45) | SMN1; SMN2RAB9ANPC1TP53LDHA | |
| SCHEMBL20256974 | 0.72 | LDHA (0.45) | LDHALDHBKDM4EALDH1A1 | |
| SCHEMBL19928398 | 0.72 | LDHA (0.49) | LDHALDHBGAAALDH1A1CAMK2D | |
| SCHEMBL18019282 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2RAB9ANPC1TP53LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9908883-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2018-03-06 | — | — | US | disclosed |