Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | LDHB | P07195 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20256988 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2RAB9AKDM4ERXFP1POLB | |
| SCHEMBL18019293 | 0.85 | LDHA (0.52) | GAAALDH1A1LDHALDHB | |
| SCHEMBL20256989 | 0.85 | LDHA (0.46) | SMN1; SMN2RAB9AKDM4ERXFP1POLB | |
| SCHEMBL15131382 | 0.85 | SMN1; SMN2 (0.41) | SMN1; SMN2RAB9AKDM4ERXFP1POLB | |
| SCHEMBL20256902 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2RAB9AKDM4ERXFP1POLB | |
| SCHEMBL10212526 | 0.83 | SMN1; SMN2 (0.40) | SMN1; SMN2RAB9AKDM4ERXFP1POLB | |
| SCHEMBL899974 | 0.76 | ABCG2 (0.44) | SMN1; SMN2RAB9AKDM4ERXFP1GAA | |
| SCHEMBL19928396 | 0.72 | LDHA (0.46) | SMN1; SMN2RAB9AKDM4ERXFP1POLB | |
| SCHEMBL20256987 | 0.72 | SMN1; SMN2 (0.45) | SMN1; SMN2RAB9AKDM4ERXFP1POLB | |
| SCHEMBL12647214 | 0.71 | KDM4E (0.49) | SMN1; SMN2RAB9AKDM4EHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10294225-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2019-05-21 | — | — | US | disclosed |
| US-20180162858-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2018-06-14 | — | — | US | disclosed |
| EP-2621493-B1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER (US) | 2016-08-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10294225-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | ACACA, ACACB, PC | SMN1; SMN2 2926/4885RAB9A 3773/4885KDM4E 1995/4885 |
| US-20180162858-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | ACACA, ACACB, PC | SMN1; SMN2 2926/4885RAB9A 3773/4885KDM4E 1995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.