Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.49 |
| ▸ | FYN | P06241 | 9/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15288627 | 0.85 | MKNK1 (0.65) | MKNK1MKNK2FYNATM | |
| SCHEMBL19928566 | 0.82 | FYN (0.45) | MKNK1MKNK2FYN | |
| SCHEMBL19928564 | 0.80 | MKNK1 (0.39) | MKNK1MKNK2EGLN1ATM | |
| SCHEMBL15288205 | 0.74 | MKNK1 (0.70) | MKNK1MKNK2FYNATM | |
| SCHEMBL15288631 | 0.74 | MKNK1 (0.47) | MKNK1MKNK2EGLN1TP53MAPT | |
| SCHEMBL15288297 | 0.73 | MKNK1 (0.63) | MKNK1MKNK2 | |
| SCHEMBL19243865 | 0.72 | MKNK1 (0.78) | MKNK1MKNK2EGLN1 | |
| SCHEMBL15288419 | 0.72 | ATM (0.45) | MKNK1MKNK2FYNTP53MAPT | |
| SCHEMBL15286166 | 0.72 | MAPT (0.47) | MKNK1MKNK2FYNTP53MAPT | |
| SCHEMBL19243868 | 0.70 | MKNK1 (0.48) | MKNK1MKNK2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9908886-B2 | Bicyclic heterocyclic derivatives as MNK1 and MNK2 modulators and uses thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-03-06 | — | — | US | disclosed |