Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 15/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15286332 | 0.86 | MKNK1 (0.55) | FYNMKNK1MKNK2 | |
| SCHEMBL19928565 | 0.82 | MKNK1 (0.49) | FYNMKNK1MKNK2 | |
| SCHEMBL15288662 | 0.78 | MKNK1 (0.55) | FYNMKNK1MKNK2 | |
| SCHEMBL19928564 | 0.74 | MKNK1 (0.39) | MKNK1MKNK2 | |
| SCHEMBL15288110 | 0.73 | MKNK1 (0.71) | FYNMKNK1MKNK2 | |
| SCHEMBL15288167 | 0.73 | MKNK1 (0.60) | FYNMKNK1MKNK2 | |
| SCHEMBL15288484 | 0.73 | MKNK1 (0.63) | FYNMKNK1MKNK2 | |
| SCHEMBL15288329 | 0.70 | MKNK1 (0.59) | FYNMKNK1MKNK2 | |
| SCHEMBL15288274 | 0.70 | MKNK1 (0.58) | FYNMKNK1MKNK2 | |
| SCHEMBL15288099 | 0.69 | MKNK1 (0.62) | FYNMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9908886-B2 | Bicyclic heterocyclic derivatives as MNK1 and MNK2 modulators and uses thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-03-06 | — | — | US | disclosed |