SCHEMBL19928646

SCHEMBL19928646

C=CCOC1C[C@H](n2ccc(N)nc2=O)O[C@@H]1COP(=O)(O)OP(=O)(O)OP(=O)(O)OC

nearest known ligand 0.54

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
POLG P54098 2/20 0.54
P2RY2 P41231 10/20 0.53
P2RY4 P51582 7/20 0.53
P2RY6 Q15077 5/20 0.53
POLB P06746 1/20 0.52
P2RY12 Q9H244 2/20 0.42
POLA1 P09884 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15343924 0.94 POLG (0.61) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL18179803 0.94 POLG (0.61) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL432220 0.94 POLG (0.61) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL22327467 0.86 POLG (0.53) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL14625872 0.86 POLB (0.51) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL24370820 0.85 POLG (0.66) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL27102637 0.85 POLG (0.66) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL19412487 0.85 POLB (0.71) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL17634950 0.84 POLG (0.42) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL17634406 0.84 POLG (0.42) POLGP2RY2P2RY4P2RY6POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9909177-B2 Pyrosequencing methods and related compositions THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2018-03-06 US disclosed