Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLG | P54098 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | P2RY2 | P41231 | 10/20 | 0.55 |
| ▸ | P2RY4 | P51582 | 6/20 | 0.55 |
| ▸ | P2RY6 | Q15077 | 5/20 | 0.55 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18179803 | 1.00 | POLG (0.61) | POLGPOLBP2RY2P2RY4P2RY6 | |
| SCHEMBL15343924 | 1.00 | POLG (0.61) | POLGPOLBP2RY2P2RY4P2RY6 | |
| SCHEMBL19928646 | 0.94 | POLG (0.54) | POLGPOLBP2RY2P2RY4P2RY6 | |
| SCHEMBL14625872 | 0.88 | POLB (0.51) | POLGPOLBP2RY2P2RY4P2RY6 | |
| SCHEMBL25631339 | 0.88 | POLG (0.67) | POLGPOLBP2RY2P2RY4P2RY6 | |
| SCHEMBL21011368 | 0.88 | POLG (0.67) | POLGPOLBP2RY2P2RY4P2RY6 | |
| SCHEMBL1333569 | 0.88 | POLG (0.67) | POLGPOLBP2RY2P2RY4P2RY6 | |
| SCHEMBL25457105 | 0.87 | POLG (0.60) | POLGPOLBP2RY2P2RY4P2RY6 | |
| SCHEMBL24370820 | 0.87 | POLG (0.66) | POLGPOLBP2RY2P2RY4P2RY6 | |
| SCHEMBL27102637 | 0.87 | POLG (0.66) | POLGPOLBP2RY2P2RY4P2RY6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12559797-B2 | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2026-02-24 | — | — | US | disclosed |
| US-20250382323-A1 | COMPOSITIONS, METHODS, AND SYSTEMS FOR DETECTING NUCLEOTIDES | AXBIO INC (US) | 2025-12-18 | — | — | US | disclosed |
| EP-4599075-A2 | COMPOSITIONS, METHODS, AND SYSTEMS FOR DETECTING NUCLEOTIDES | Axbio Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| US-20240318245-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2024-09-26 | — | — | US | disclosed |
| WO-2024077111-A2 | COMPOSITIONS, METHODS, AND SYSTEMS FOR DETECTING NUCLEOTIDES | Axbio Inc. (US) | 2024-04-11 | — | — | WO | disclosed |
| US-11939631-B2 | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2024-03-26 | — | — | US | disclosed |
| US-20210381043-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-12-09 | — | — | US | disclosed |
| US-20200208211-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-07-02 | — | — | US | disclosed |
| US-20190136308-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-05-09 | — | — | US | disclosed |
| US-10000801-B2 | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-06-19 | — | — | US | disclosed |
| US-20170114403-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-04-27 | — | — | US | disclosed |
| US-9528151-B2 | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-12-27 | — | — | US | disclosed |
| US-20140315191-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-10-23 | — | — | US | disclosed |
| US-20130280700-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2013-10-24 | — | — | US | disclosed |
| US-8298792-B2 | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-10-30 | — | — | US | disclosed |
| US-20120021408-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2012-01-26 | — | — | US | disclosed |
| US-7883869-B2 | for sequencing single-stranded DNA by employing a nanopore and modified nucleotides | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2011-02-08 | — | — | US | disclosed |
| US-20100092952-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12559797-B2 | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators | POLN, DNMT3A, POLRMT | POLG 38/4885POLB 5/4885P2RY2 3179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.