Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.41 |
| ▸ | INSR | P06213 | 7/20 | 0.41 |
| ▸ | IGF1R | P08069 | 7/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.39 |
| ▸ | ULK1 | O75385 | 1/20 | 0.39 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19921100 | 0.86 | ALK (0.52) | EGFRALKINSRIGF1RMAP3K7 | |
| SCHEMBL19921135 | 0.85 | CCNK (0.50) | EGFRALKMAP3K7JAK2SRC | |
| SCHEMBL19921137 | 0.81 | ALK (0.62) | EGFRALKINSRIGF1RMAP3K7 | |
| SCHEMBL19921127 | 0.80 | ALK (0.50) | ALKINSRIGF1RMAP3K7TNK2 | |
| SCHEMBL19921198 | 0.79 | ALK (0.51) | EGFRALKINSRIGF1RJAK2 | |
| SCHEMBL19921199 | 0.79 | ALK (0.49) | EGFRALKINSRIGF1RMAP3K7 | |
| SCHEMBL22730041 | 0.75 | IRAK4 (0.45) | EGFRALKJAK2TNK2CCNK | |
| SCHEMBL20546932 | 0.74 | ALK (0.65) | EGFRALKINSRIGF1RMAP3K7 | |
| SCHEMBL19921120 | 0.74 | ALK (0.70) | EGFRALKINSRIGF1RCAMK2D | |
| SCHEMBL19921124 | 0.74 | ALK (0.56) | EGFRALKINSRIGF1RMAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Xiamen University (CN) | 2018-03-07 | — | — | EP | disclosed |