Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 2/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | CCND3 | P30281 | 2/20 | 0.50 |
| ▸ | CDK9 | P50750 | 2/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | BRD2 | P25440 | 2/20 | 0.45 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22730041 | 0.89 | IRAK4 (0.45) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL19929891 | 0.85 | EGFR (0.41) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL19921100 | 0.85 | ALK (0.52) | ALKPTK2EGFRMAP3K7JAK2 | |
| SCHEMBL19921074 | 0.84 | PTK2 (0.67) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL19921112 | 0.84 | PTK2 (0.62) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL19921089 | 0.82 | AXL (0.53) | CDK2ALKPTK2EGFRMAP3K7 | |
| SCHEMBL22730040 | 0.81 | IRAK4 (0.42) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL19921129 | 0.80 | PDE5A (0.46) | AURKA | |
| SCHEMBL19921137 | 0.79 | ALK (0.62) | CDK2ALKPTK2EGFRMAP3K7 | |
| SCHEMBL19929884 | 0.79 | PTK2 (0.37) | CCNA2CDK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | claimed |
| EP-3290420-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Xiamen University (CN) | 2018-03-07 | — | — | EP | claimed |