Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 7/20 | 0.43 |
| ▸ | CDK7 | P50613 | 6/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 2/20 | 0.42 |
| ▸ | NPM1 | P06748 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 5/20 | 0.41 |
| ▸ | ROS1 | P08922 | 5/20 | 0.41 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22754146 | 0.88 | JAK2 (0.46) | ALKCDK9CDK7INSRPTK2 | |
| SCHEMBL19921177 | 0.84 | PDE5A (0.44) | ALKTTKCDK9CDK7MET | |
| SCHEMBL19921089 | 0.81 | AXL (0.53) | ALKTTKCDK7DCLK1INSR | |
| SCHEMBL19921159 | 0.79 | PTK2 (0.58) | ALKTTKCDK9CDK7DCLK1 | |
| SCHEMBL19929862 | 0.78 | PIP4K2C (0.33) | — | |
| SCHEMBL19929884 | 0.77 | PTK2 (0.37) | PTK2 | |
| SCHEMBL19921063 | 0.77 | ALK (0.68) | ALKTTKCDK7DCLK1INSR | |
| SCHEMBL19929896 | 0.76 | PTK2 (0.42) | ALKCDK9CDK7INSREGFR | |
| SCHEMBL19921217 | 0.75 | ALK (0.72) | ALKINSRNPM1METEGFR | |
| SCHEMBL19929899 | 0.75 | KDM4E (0.47) | PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | disclosed |
| EP-3290420-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Xiamen University (CN) | 2018-03-07 | — | — | EP | disclosed |