Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.46 |
| ▸ | JAK3 | P52333 | 6/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.45 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 4/20 | 0.36 |
| ▸ | INSR | P06213 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.36 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19929897 | 0.88 | ALK (0.45) | PTK2ALKCDK7CDK9INSR | |
| SCHEMBL19921180 | 0.83 | ALK (0.46) | JAK2JAK3PTK2ALK | |
| SCHEMBL19921112 | 0.80 | PTK2 (0.62) | JAK2JAK3PTK2ALKCDK9 | |
| SCHEMBL19929884 | 0.80 | PTK2 (0.37) | PTK2IGF1RBRAFTNNI3K | |
| SCHEMBL19929896 | 0.79 | PTK2 (0.42) | PTK2ALKCDK7CDK9INSR | |
| SCHEMBL19921167 | 0.78 | PTK2 (0.51) | JAK2JAK3PTK2ALKINSR | |
| SCHEMBL19929899 | 0.77 | KDM4E (0.47) | PTK2 | |
| SCHEMBL19930114 | 0.76 | ALK (0.46) | JAK2JAK3PTK2ALKCDK7 | |
| SCHEMBL19929862 | 0.76 | PIP4K2C (0.33) | — | |
| SCHEMBL20546932 | 0.76 | ALK (0.65) | JAK2JAK3PTK2ALKCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | disclosed |