Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18202172 | 0.80 | HTR2A (0.55) | PBRM1HTR2AHTR2CSMARCA4KDM4E | |
| SCHEMBL20080071 | 0.78 | CHRM2 (0.44) | MTNR1AMTNR1BCHRM2CHRNA7HTR2A | |
| SCHEMBL20080068 | 0.77 | HTR6 (0.43) | MTNR1AMTNR1BCHRM2CHRNA7HTR2A | |
| SCHEMBL19960979 | 0.77 | HTR2A (0.38) | PBRM1HTR2AHTR2CSMARCA4KDM4E | |
| Hydrochloric Acid SCHEMBL7097944 | 0.71 | HTR2C (0.51) | CHRM2CHRNA7HTR2AHTR2CKDM4E | |
| SCHEMBL7274363 | 0.69 | KDM4E (0.40) | KDM4EALDH1A1 | |
| SCHEMBL7381588 | 0.68 | BRD4 (0.43) | HTR2AHTR2CPTPN1KDM4EALDH1A1 | |
| SCHEMBL1092483 | 0.63 | MTNR1A (0.41) | MTNR1AMTNR1BCHRM2CHRNA7HTR2A | |
| SCHEMBL12355447 | 0.61 | CHRNA7 (0.46) | MTNR1AMTNR1BCHRM2CHRNA7PBRM1 | |
| SCHEMBL18456933 | 0.61 | PTGDR2 (0.53) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312179-A1 | FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-04-25 | — | — | EP | disclosed |
| EP-3290419-A1 | FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-03-07 | — | — | EP | disclosed |