Sugi Predict

Sugi Predict / Compounds / SCHEMBL1993418

SCHEMBL1993418

SCHEMBL1993418

Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)cc3c2C(=O)NC3)ccc1F

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 12/20 0.75
▸ FER P16591 8/20 0.62
▸ CHEK1 O14757 2/20 0.42
▸ PAK4 O96013 2/20 0.42
▸ RET P07949 2/20 0.42
▸ PHKG2 P15735 2/20 0.42
▸ PDGFRA P16234 2/20 0.42
▸ KDR P35968 2/20 0.42
▸ JAK3 P52333 2/20 0.42
▸ JAK2 O60674 2/20 0.42
▸ ROCK2 O75116 2/20 0.42
▸ MAP4K4 O95819 2/20 0.42
▸ HCK P08631 2/20 0.42
▸ ROS1 P08922 2/20 0.42
▸ PIM1 P11309 2/20 0.42
▸ PRKACA P17612 2/20 0.42
▸ MARK3 P27448 2/20 0.42
▸ LTK P29376 2/20 0.42
▸ CSNK1A1 P48729 2/20 0.42
▸ CLK2 P49760 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21031602 1.00 SYK (0.75) SYKFERCHEK1PAK4RET
SCHEMBL22475355 1.00 SYK (0.75) SYKFERCHEK1PAK4RET
SCHEMBL1990162 0.89 SYK (0.59) SYKFERJAK2TYK2BTK
SCHEMBL1990177 0.89 SYK (0.59) SYKFERJAK2TYK2BTK
SCHEMBL25403128 0.88 SYK (0.81) SYKFERCHEK1PAK4RET
SCHEMBL16751349 0.86 SYK (0.56) SYKFERTYK2BTK
SCHEMBL21032624 0.85 SYK (1.00) SYKFERCHEK1PAK4RET
SCHEMBL1989354 0.85 SYK (1.00) SYKFERCHEK1PAK4RET
SCHEMBL22475426 0.83 SYK (0.53) SYKFERTYK2BTK
SCHEMBL14930598 0.83 SYK (0.53) SYKFERTYK2BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220306634-A1 FUSED HETEROAROMATIC PYRROLIDINONES TAKEDA SAN DIEGO, INC. 2022-09-29 — — US claimed
US-20180141951-A1 FUSED HETEROAROMATIC PYRROLIDINONES CALITHERA BIOSCIENCES, INC. 2018-05-24 — — US claimed
US-9108970-B2 Fused heteroaromatic pyrrolidinones TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-08-18 — — US claimed
EP-2516434-B1 FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS TAKEDA PHARMACEUTICAL (JP) 2015-05-27 — — EP claimed
US-20130245031-A1 FUSED HETEROAROMATIC PYRROLIDINONES TAKEDA PHAMACEUTICAL COMPANY LIMITED (JP) 2013-09-19 — — US claimed
US-8440689-B2 Fused heteroaromatic pyrrolidinones TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-05-14 — — US claimed
US-20130116260-A1 FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-05-09 — — US claimed
US-20110152273-A1 FUSED HETEROAROMATIC PYRROLIDINONES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-23 — — US claimed
US-20230295171-A1 FUSED HETEROAROMATIC PYRROLIDINONES WELLS THERAPEUTICS, INC. 2023-09-21 — — US disclosed
US-20230295171-A1 FUSED HETEROAROMATIC PYRROLIDINONES WELLS THERAPEUTICS, INC. 2023-09-21 — — US disclosed
US-20230295171-A1 FUSED HETEROAROMATIC PYRROLIDINONES WELLS THERAPEUTICS, INC. 2023-09-21 — — US disclosed
US-20220306634-A1 FUSED HETEROAROMATIC PYRROLIDINONES TAKEDA SAN DIEGO, INC. 2022-09-29 — — US disclosed
US-11077111-B2 Use of fused heteroaromatic pyrrolidones for treatment and prevention of diseases in animals BAYER ANIMAL HEALTH GMBH (DE) 2021-08-03 — — US disclosed
EP-3825316-A1 FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS Takeda Pharmaceutical Company Limited (JP) 2021-05-26 — — EP disclosed
US-20130116260-A1 FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-05-09 — — US disclosed
US-20130116260-A1 FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-05-09 — — US disclosed
WO-2011079051-A1 FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-30 — — WO disclosed
US-20110152273-A1 FUSED HETEROAROMATIC PYRROLIDINONES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-23 — — US disclosed
US-20110152273-A1 FUSED HETEROAROMATIC PYRROLIDINONES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-23 — — US disclosed
US-20110152273-A1 FUSED HETEROAROMATIC PYRROLIDINONES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11077111-B2 Use of fused heteroaromatic pyrrolidones for treatment and prevention of diseases in animals HRH4, HRH2, CAT SYK 579/4885FER 436/4885CHEK1 4533/4885
US-20220306634-A1 FUSED HETEROAROMATIC PYRROLIDINONES SYK, ZAP70, LYN SYK 1/4885FER 62/4885CHEK1 470/4885
US-20180141951-A1 FUSED HETEROAROMATIC PYRROLIDINONES SYK, ZAP70, LYN SYK 1/4885FER 62/4885CHEK1 470/4885
US-20130116260-A1 FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS SYK, BTK, LYN SYK 1/4885FER 45/4885CHEK1 403/4885
US-20130245031-A1 FUSED HETEROAROMATIC PYRROLIDINONES SYK, ZAP70, LYN SYK 1/4885FER 62/4885CHEK1 470/4885
US-20110152273-A1 FUSED HETEROAROMATIC PYRROLIDINONES SYK, ZAP70, LYN SYK 1/4885FER 62/4885CHEK1 470/4885
US-20230295171-A1 FUSED HETEROAROMATIC PYRROLIDINONES SYK, ZAP70, LYN SYK 1/4885FER 62/4885CHEK1 470/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.