Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.75 |
| ▸ | FER | P16591 | 8/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | PAK4 | O96013 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | HCK | P08631 | 2/20 | 0.42 |
| ▸ | ROS1 | P08922 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | PRKACA | P17612 | 2/20 | 0.42 |
| ▸ | MARK3 | P27448 | 2/20 | 0.42 |
| ▸ | LTK | P29376 | 2/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1993418 | 1.00 | SYK (0.75) | SYKFERCHEK1PAK4RET | |
| SCHEMBL22475355 | 1.00 | SYK (0.75) | SYKFERCHEK1PAK4RET | |
| SCHEMBL1990162 | 0.89 | SYK (0.59) | SYKFERJAK2TYK2BTK | |
| SCHEMBL1990177 | 0.89 | SYK (0.59) | SYKFERJAK2TYK2BTK | |
| SCHEMBL25403128 | 0.88 | SYK (0.81) | SYKFERCHEK1PAK4RET | |
| SCHEMBL16751349 | 0.86 | SYK (0.56) | SYKFERTYK2BTK | |
| SCHEMBL21032624 | 0.85 | SYK (1.00) | SYKFERCHEK1PAK4RET | |
| SCHEMBL1989354 | 0.85 | SYK (1.00) | SYKFERCHEK1PAK4RET | |
| SCHEMBL22475426 | 0.83 | SYK (0.53) | SYKFERTYK2BTK | |
| SCHEMBL14930598 | 0.83 | SYK (0.53) | SYKFERTYK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3825316-A1 | FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2021-05-26 | — | — | EP | disclosed |
| EP-3489236-A1 | PROCESS FOR THE PREPARATION OF FUSED HETEROAROMATIC PYRROLIDINONES | Takeda Pharmaceutical Company Limited (JP) | 2019-05-29 | — | — | EP | disclosed |