Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.44 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.33 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19483324 | 0.84 | KDM4E (0.48) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL19483322 | 0.84 | KDM4E (0.48) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL20235708 | 0.83 | KDM4E (0.52) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL20650879 | 0.83 | TP53BP1 (0.33) | CTSK | |
| SCHEMBL26654410 | 0.83 | TP53BP1 (0.33) | CTSK | |
| SCHEMBL12055210 | 0.81 | KDM4E (0.48) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL16231519 | 0.81 | KDM4E (0.48) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL20235709 | 0.79 | KDM4E (0.47) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL20850017 | 0.78 | CTSK (0.48) | MAPK1CA1CA2CTSK | |
| SCHEMBL20445424 | 0.78 | CTSK (0.35) | EPHX1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180066070-A1 | ACETYLATED PCSK9 | UNIVERSITAT ZURICH (CH) | 2018-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180066070-A1 | ACETYLATED PCSK9 | PCSK9, CETP, PCSK7 | KDM4E 631/4885MAPK1 3629/4885HIF1A 3792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.