Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.47 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | ALB | P02768 | 3/20 | 0.34 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16231519 | 1.00 | KDM4E (0.48) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL20235708 | 0.90 | KDM4E (0.52) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL19483461 | 0.88 | MTNR1A (0.40) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL25590403 | 0.87 | FOLH1 (0.37) | KDM4EMAPK1HIF1AFOLH1SIRT5 | |
| SCHEMBL22800728 | 0.85 | SIRT6 (0.35) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL21913856 | 0.84 | ALDH1A1 (0.43) | FOLH1ALBTSHRALDH1A1 | |
| SCHEMBL763069 | 0.84 | MEN1 (0.53) | FOLH1SIRT6SIRT1SMN1; SMN2EPHX1 | |
| SCHEMBL25651291 | 0.83 | GLP1R (0.43) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL25651303 | 0.83 | GLP1R (0.43) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL23944184 | 0.83 | ALDH1A1 (0.40) | FOLH1ALBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200223889-A1 | Bicyclic Compounds Capable of Binding to Melanocortin 4 Receptor | NOVO NORDISK A/S (DK) | 2020-07-16 | — | — | US | disclosed |
| US-20180155760-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | BROAD INST INC (US) | 2018-06-07 | — | — | US | disclosed |
| US-9856509-B2 | Fluorescent substrates for determining lysine modifying enzyme activity | THE BROAD INSTITUTE, INC. (US) | 2018-01-02 | — | — | US | disclosed |
| US-20140335550-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | THE BROAD INSTITUTE, INC. (US) | 2014-11-13 | — | — | US | disclosed |
| US-20110319493-A1 | HISTONE DEACETYLASES, AND USES RELATED THERETO | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110313045-A1 | HISTONE DEACETYLASES, AND USES RELATED THERETO | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319493-A1 | HISTONE DEACETYLASES, AND USES RELATED THERETO | HDAC1, HDAC8, HDAC11 | KDM4E 222/4885MAPK1 3413/4885HIF1A 1059/4885 |
| US-20200223889-A1 | Bicyclic Compounds Capable of Binding to Melanocortin 4 Receptor | MC4R, MC5R, MC3R | KDM4E 2846/4885MAPK1 2229/4885HIF1A 2088/4885 |
| US-20110313045-A1 | HISTONE DEACETYLASES, AND USES RELATED THERETO | HDAC1, HDAC8, HDAC11 | KDM4E 222/4885MAPK1 3413/4885HIF1A 1059/4885 |
| US-20180155760-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | KDM1A, MAN2B1, KDM3A | KDM4E 150/4885MAPK1 2405/4885HIF1A 3295/4885 |
| US-20140335550-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | MAN2B1, KDM1A, KDM3A | KDM4E 219/4885MAPK1 2901/4885HIF1A 3309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.