Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 3/20 | 0.45 |
| ▸ | CES1 | P23141 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | SCN1A | P35498 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5678485 | 0.90 | LMNA (0.53) | LMNACES2CES1TDP1CYP1A2 | |
| SCHEMBL28920596 | 0.85 | TDP1 (0.43) | LMNATDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11850307 | 0.85 | LMNA (0.51) | LMNAL3MBTL1CES2CES1TDP1 | |
| SCHEMBL27267377 | 0.83 | TDP1 (0.41) | LMNATDP1CYP1A2CYP2D6HPGD | |
| SCHEMBL4050408 | 0.82 | LMNA (0.52) | LMNATDP1CYP1A2CYP2D6HPGD | |
| SCHEMBL11530129 | 0.82 | LMNA (0.49) | LMNAL3MBTL1CES2CES1TDP1 | |
| SCHEMBL26179405 | 0.81 | TSHR (0.46) | LMNATDP1CYP1A2CYP2D6HPGD | |
| Hydrochloric Acid SCHEMBL9134016 | 0.80 | LMNA (0.44) | LMNAL3MBTL1CES2CES1TDP1 | |
| SCHEMBL21673638 | 0.80 | TSHR (0.48) | LMNATDP1CYP1A2CYP2D6HPGD | |
| SCHEMBL27851129 | 0.80 | LMNA (0.50) | LMNAL3MBTL1CES2CES1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848372-A1 | FUSED TRICYCLIC PYRIDAZINONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | Novartis AG (CH) | 2021-07-14 | — | — | EP | disclosed |
| EP-3504214-B1 | FUSED TRICYCLIC PYRIDAZINONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2020-12-02 | — | — | EP | disclosed |
| WO-2018042303-A1 | FUSED TRICYCLIC PYRIDAZINONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2018-03-08 | — | — | WO | disclosed |