Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19936464 | 0.86 | SMN1; SMN2 (0.32) | SMN1; SMN2BRPF1NLRP3 | |
| SCHEMBL19936555 | 0.77 | MAPK1 (0.35) | SMN1; SMN2MAPTPOLBCYP1A2CYP2C19 | |
| SCHEMBL19936593 | 0.77 | MAPK1 (0.36) | SMN1; SMN2MAPTPOLBCYP1A2CYP2C9 | |
| SCHEMBL19936419 | 0.71 | ALDH1A1 (0.33) | SMN1; SMN2 | |
| SCHEMBL14819397 | 0.69 | CACNA1H (0.45) | — | |
| SCHEMBL14819412 | 0.69 | NOTUM (0.39) | SMN1; SMN2ALPLCYP1A2CYP2C19 | |
| SCHEMBL14819607 | 0.69 | NOTUM (0.40) | SMN1; SMN2MAPK14BRPF1MAPTPOLB | |
| SCHEMBL14819764 | 0.69 | NPC1 (0.41) | SMN1; SMN2MAPTCYP1A2CYP2C19 | |
| SCHEMBL14819545 | 0.68 | NPC1 (0.43) | SMN1; SMN2MAPTPOLBTDP1CYP1A2 | |
| SCHEMBL19936623 | 0.68 | MAPT (0.33) | SMN1; SMN2NLRP3MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594555-B1 | HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR | ASKA PHARM CO LTD (JP) | 2018-03-07 | — | — | EP | disclosed |