Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.31 |
| ▸ | PPARD | Q03181 | 2/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19936521 | 0.92 | MAPT (0.33) | MAPTSMN1; SMN2KDM4EMEN1ALDH1A1 | |
| SCHEMBL19936575 | 0.85 | FFAR1 (0.34) | MAPTLMNAFFAR1PPARDTP53 | |
| SCHEMBL19936419 | 0.76 | ALDH1A1 (0.33) | SMN1; SMN2KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL14805011 | 0.74 | MAPT (0.46) | MAPTSMN1; SMN2KDM4ELMNAPOLB | |
| SCHEMBL14800580 | 0.70 | AGPAT2 (0.45) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL3436487 | 0.68 | NPC1 (0.43) | MAPTSMN1; SMN2KDM4EMEN1ALDH1A1 | |
| SCHEMBL19936587 | 0.68 | SMN1; SMN2 (0.34) | MAPTSMN1; SMN2NLRP3POLB | |
| SCHEMBL14805030 | 0.68 | GAA (0.49) | MAPTKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL14805055 | 0.68 | NOTUM (0.41) | MAPTSMN1; SMN2POLBTP53 | |
| SCHEMBL14805063 | 0.68 | NOTUM (0.41) | MAPTSMN1; SMN2MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594555-B1 | HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR | ASKA PHARM CO LTD (JP) | 2018-03-07 | — | — | EP | disclosed |