Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.82 |
| ▸ | HTR7 | P34969 | 2/20 | 0.82 |
| ▸ | HTR6 | P50406 | 2/20 | 0.82 |
| ▸ | OPRM1 | P35372 | 15/20 | 0.79 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.78 |
| ▸ | ICMT | O60725 | 2/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18886950 | 0.88 | OPRM1 (1.00) | HTR1AHTR7HTR6OPRM1OPRD1 | |
| SCHEMBL18899397 | 0.88 | OPRM1 (1.00) | HTR1AHTR7HTR6OPRM1OPRD1 | |
| SCHEMBL12542194 | 0.88 | OPRM1 (1.00) | HTR1AHTR7HTR6OPRM1OPRD1 | |
| SCHEMBL12542671 | 0.88 | OPRM1 (0.76) | HTR1AHTR7HTR6OPRM1OPRD1 | |
| SCHEMBL12542271 | 0.86 | OPRM1 (1.00) | HTR1AHTR7HTR6OPRM1OPRD1 | |
| SCHEMBL19937001 | 0.86 | OPRM1 (1.00) | HTR1AHTR7HTR6OPRM1OPRD1 | |
| SCHEMBL21559960 | 0.83 | HTR1A (0.84) | HTR1AHTR7HTR6OPRM1OPRD1 | |
| SCHEMBL12542131 | 0.83 | OPRM1 (1.00) | HTR1AHTR7HTR6OPRM1OPRD1 | |
| SCHEMBL19921826 | 0.83 | OPRM1 (1.00) | HTR1AHTR7HTR6OPRM1OPRD1 | |
| SCHEMBL12542130 | 0.83 | OPRM1 (1.00) | HTR1AHTR7HTR6OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290415-A1 | OPIOID RECEPTOR LIGANDS AND METHODS OF USING AND MAKING SAME | Trevena, Inc. (US) | 2018-03-07 | — | — | EP | disclosed |